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Neurotransmitter Release At Cholinergic Synapses

  • Cholinergic synapses are chemical synapses that that use acetylcholine molecules as the neurotransmitter.
  • Synaptic transmission begins when an action potential or electrochemical image descriptionimpulse reaches the synaptic knob of a presynaptic neuron.
An image showing the action potential passing through the axon of the presynaptic neuron (which is myelinated)
An image showing the action potential passing through the axon of the presynaptic neuron (which is myelinated)
An image showing the action potential passing through the axon of the presynaptic neuron (which is myelinated)
An image showing the action potential passing through the axon of the presynaptic neuron (which is myelinated)
An image showing the action potential passing through the axon of the presynaptic neuron (which is myelinated)
An image showing the action potential passing through the axon of the presynaptic neuron (which is myelinated)
  • image descriptionCa2+ channels open in response, and Ca2+ ions diffuse into the synaptic knob. The influx of Ca2+ causes many of the synaptic vesicles to fuse with the presynaptic membrane.
An image showing opening process of the calcium channels after stimulation, Ca+2 ions diffuse into synaptic knob
An image showing opening process of the calcium channels after stimulation, Ca+2 ions diffuse into synaptic knob
An image showing opening process of the calcium channels after stimulation, Ca+2 ions diffuse into synaptic knob
An image showing opening process of the calcium channels after stimulation, Ca+2 ions diffuse into synaptic knob
An image showing opening process of the calcium channels after stimulation, Ca+2 ions diffuse into synaptic knob
An image showing opening process of the calcium channels after stimulation, Ca+2 ions diffuse into synaptic knob
An image showing opening process of the calcium channels after stimulation, Ca+2 ions diffuse into synaptic knob
An image showing opening process of the calcium channels after stimulation, Ca+2 ions diffuse into synaptic knob
An image showing opening process of the calcium channels after stimulation, Ca+2 ions diffuse into synaptic knob
An image showing opening process of the calcium channels after stimulation, Ca+2 ions diffuse into synaptic knob
An image showing the vesicles fusion of the presynaptic neuron causing the releasing of the transmitter molecules (ACh)
An image showing the vesicles fusion of the presynaptic neuron causing the releasing of the transmitter molecules (ACh)
An image showing the vesicles fusion of the presynaptic neuron causing the releasing of the transmitter molecules (ACh)
An image showing the vesicles fusion of the presynaptic neuron causing the releasing of the transmitter molecules (ACh)
An image showing the vesicles fusion of the presynaptic neuron causing the releasing of the transmitter molecules (ACh)
An image showing the vesicles fusion of the presynaptic neuron causing the releasing of the transmitter molecules (ACh)
An image showing the vesicles fusion of the presynaptic neuron causing the releasing of the transmitter molecules (ACh)
An image showing the vesicles fusion of the presynaptic neuron causing the releasing of the transmitter molecules (ACh)
An image showing the vesicles fusion of the presynaptic neuron causing the releasing of the transmitter molecules (ACh)
  • A few of these molecules diffuse across the synaptic cleft and bind to the acetylcholine receptors that are embedded in the membrane of the postsynaptic neuron.