Oxygen–hemoglobin Dissociation Curve | How CO Affects Oxy-Hemoglobin Saturation
Oxygen-Hemoglobin Dissociation Curve | How pH Affects Oxygen-Hemoglobin Dissociation Curve
A low (= acidic) blood plasma pH of 7.2 causes the O2-Hb saturation curve to shift about 15% to the right of normal (= pH 7.4).
In contrast, an elevated (= alkaline or basic) blood plasma pH of 7.6 causes the O2-Hb saturation curve to shift about 15% to the left of normal.
As blood plasma pH decreases (= becomes more acidic), H+ ions increasingly bind to hemoglobin amino acids, which lessens hemoglobin’s affinity for O2. This is referred to as the Bohr effect.
The situation reverses as plasma pH increase (= becomes more alkaline; basic).