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Oxygen-Hemoglobin Dissociation Curve | How pH Affects Oxygen-Hemoglobin Dissociation Curve

The normal ph as demonstrated in a graph

Acidic Blood:

A low (= acidic) blood plasma pH of 7.2 causes the O2-Hb saturation curve to shift about 15% to the right of normal (= pH 7.4).

 

An animation that demonstrates the low blood plasma
An animation that demonstrates the low blood plasma
An animation that demonstrates the low blood plasma
An animation that demonstrates the low blood plasma
An animation that demonstrates the low blood plasma
An animation that demonstrates the low blood plasma
An animation that demonstrates the low blood plasma
An animation that demonstrates the low blood plasma
An animation that demonstrates the low blood plasma
An animation that demonstrates the low blood plasma
An animation that demonstrates the low blood plasma
An illustration that demonstrates the low blood plasma ph effect on oxygen-hemoglobin dissociation curve
A low blood plasma pH of 7.2

Alkaline Blood:

In contrast, an elevated (= alkaline or basic) blood plasma pH of 7.6 causes the O2-Hb saturation curve to shift about 15% to the left of normal.

An animation that demonstrates elevated blood plasma
An animation that demonstrates elevated blood plasma
An animation that demonstrates elevated blood plasma
An animation that demonstrates elevated blood plasma
An animation that demonstrates elevated blood plasma
An animation that demonstrates elevated blood plasma
An animation that demonstrates elevated blood plasma
An animation that demonstrates elevated blood plasma
An animation that demonstrates elevated blood plasma
An animation that demonstrates elevated blood plasma
An animation that demonstrates elevated blood plasma
An animation that demonstrates elevated blood plasma effect on oxygen-hemoglobin dissociation curve
An elevated blood plasma pH of 7.6

As blood plasma pH decreases (= becomes more acidic), H+ ions increasingly bind to hemoglobin amino acids, which lessens hemoglobin’s affinity for O2. This is referred to as the Bohr effect.

The situation reverses as plasma pH increase (= becomes more alkaline; basic).

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An animation that demonstrates elevated blood plasma effect on oxygen-hemoglobin dissociation curve

An illustration that demonstrates the low blood plasma ph effect on oxygen-hemoglobin dissociation curve